Methylammonium Resistance in Aspergillus nidulans

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Methylammonium resistance in Aspergillus nidulans.

Mutants of Aspergillus nidulans resistant to methylammonium toxicity are simultaneously derepressed in the presence of ammonium for apparently all ammonium-repressible activities. Enzyme assays directly demonstrate derepression of nitrate, nitrite, and hydroxylamine reductases, xanthine dehydrogenase, urate oxidase, and allantoinase, whereas in vivo tests show that ammonium and methylammonium r...

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Resistance to various inhibitors in Aspergillus nidulans.

Resistant strains of Aspergillus nidulans were obtained by one-step selection on high concentrations of various inhibitors; each strain was mutant in a different gene conferring resistance to actidione (Act), p-fluorophenylalanine (p f ) , teoquil ( te) , iodoacetate (Iod) or malachite green (mg). Some mutant alleles have been firmly, others tentatively, located. For comparative purposes attemp...

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Aspergillus nidulans

Light-dependent conidiation in the filamentous ascomycete, Aspergillus nidulans, is contingent on the allelic state of the velvet (veA) gene. Light dependence is abolished by a mutation in this gene (veAl) , which allows conidiation to occur in the absence of light. We have isolated and characterized six extragenic suppressors of veAl that restore the light-dependent conidiation phenotype. Alle...

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Mitosis in Aspergillus nidulans.

Mitosis in growing hyphae of haploid and diploid Aspergillus nidulans has been studied with the light microscope in Helly-fixed preparations. At the periphery of the nucleus a sharply defined granule is invariably found which has strong affinity for acid fuchsin. Mitosis begins with the duplication of this granule and the development inside the nucleus of a gradually lengthening fibre between t...

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Terbinafine resistance mediated by salicylate 1-monooxygenase in Aspergillus nidulans.

Resistance to antifungal agents is a recurring and growing problem among patients with systemic fungal infections. UV-induced Aspergillus nidulans mutants resistant to terbinafine have been identified, and we report here the characterization of one such gene. A sib-selected, 6.6-kb genomic DNA fragment encodes a salicylate 1-monooxygenase (salA), and a fatty acid synthase subunit (fasC) confers...

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 1969

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.98.3.1284-1293.1969